Cadherin‐13 gene is associated with hyperactive/impulsive symptoms in attention/deficit hyperactivity disorder
Copyright policy )Cadherin‐13 gene is associated with hyperactive/impulsive symptoms in attention/deficit hyperactivity disorder
Several efforts have been made to find new genetic risk variants which explain the high heritability of ADHD. At the genome level, genes involved in neurodevelopmental pathways were pointed as candidates.CDH13andCTNNA2genes are within GWAS top hits in ADHD and there are emerging notions about their contribution to ADHD pathophysiology. The main goal of this study is to test the association between SNPs inCDH13andCTNNA2genes and ADHD across the life cycle in subjects with ADHD. This study included 1,136 unrelated ADHD cases and 946 individuals without ADHD. No significant association betweenCDH13and CTNNA2was observed between cases and controls across different samples (P ≥ 0.096 for all comparisons). No allele was significantly more transmitted than expected from parents to ADHD probands. TheCDH13 rs11150556 CCgenotype was associated with more hyperactive/impulsive symptoms in youths with ADHD (children/adolescents clinical sample: F = 7.666,P = 0.006, FDRP‐value = 0.032; Pelotas Birth Cohort sample: F = 6.711,P = 0.011, FDRP‐value = 0.032). Although there are many open questions regarding the role of neurodevelopmental genes in ADHD symptoms, the present study suggests thatCDH13is associated with hyperactive/impulsive symptoms in youths with ADHD. © 2015 Wiley Periodicals, Inc.
- Universidade de São Paulo Brazil
- Federal University of Rio de Janeiro Brazil
- Universidade Federal de Pelotas Brazil
- UNIVERSIDADE DE SAO PAULO Brazil
Adult, Male, Psychiatric Status Rating Scales, Adolescent, Hyperkinesis, Cadherins, Prognosis, Polymorphism, Single Nucleotide, Severity of Illness Index, Cohort Studies, Phenotype, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Impulsive Behavior, Humans, Female, Child, Life Style, Genetic Association Studies, Follow-Up Studies
Adult, Male, Psychiatric Status Rating Scales, Adolescent, Hyperkinesis, Cadherins, Prognosis, Polymorphism, Single Nucleotide, Severity of Illness Index, Cohort Studies, Phenotype, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Impulsive Behavior, Humans, Female, Child, Life Style, Genetic Association Studies, Follow-Up Studies
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