Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus
Copyright policy )Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus
The recent emergence of Wuhan coronavirus (2019-nCoV) puts the world on alert. 2019-nCoV is reminiscent of the SARS-CoV outbreak in 2002 to 2003. Our decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. One of the goals of SARS-CoV research was to build an atomic-level iterative framework of virus-receptor interactions to facilitate epidemic surveillance, predict species-specific receptor usage, and identify potential animal hosts and animal models of viruses. Based on the sequence of 2019-nCoV spike protein, we apply this predictive framework to provide novel insights into the receptor usage and likely host range of 2019-nCoV. This study provides a robust test of this reiterative framework, providing the basic, translational, and public health research communities with predictive insights that may help study and battle this novel 2019-nCoV.
- University of Minnesota United States
- University of Minnesota Crookston United States
- University of North Carolina at Greensboro United States
- University of Minesota United States
- UNIV OF NORTH CAROLINA CHAPEL HILL
Models, Molecular, Animal reservoir, China, SARS coronavirus, Pneumonia, Viral, Immunology, bats, bat, Peptidyl-Dipeptidase A, Microbiology, Host Specificity, Betacoronavirus, Human-to-human transmission, Protein Domains, Chiroptera, Virology, Animals, Humans, Animalia, Amino Acid Sequence, Chordata, Phylogeny, SARS-CoV-2, COVID-19, Biodiversity, Angiotensin-converting enzyme 2 (ACE2), Virus-Cell Interactions, Cross-species transmission, Severe acute respiratory syndrome-related coronavirus, Insect Science, Spike Glycoprotein, Coronavirus, Mammalia, Receptors, Virus, Angiotensin-Converting Enzyme 2, Coronavirus Infections, Sequence Alignment
Models, Molecular, Animal reservoir, China, SARS coronavirus, Pneumonia, Viral, Immunology, bats, bat, Peptidyl-Dipeptidase A, Microbiology, Host Specificity, Betacoronavirus, Human-to-human transmission, Protein Domains, Chiroptera, Virology, Animals, Humans, Animalia, Amino Acid Sequence, Chordata, Phylogeny, SARS-CoV-2, COVID-19, Biodiversity, Angiotensin-converting enzyme 2 (ACE2), Virus-Cell Interactions, Cross-species transmission, Severe acute respiratory syndrome-related coronavirus, Insect Science, Spike Glycoprotein, Coronavirus, Mammalia, Receptors, Virus, Angiotensin-Converting Enzyme 2, Coronavirus Infections, Sequence Alignment
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