Centromere protein b-null mice display decreasing reproductive performance through successive generations of breeding due to diminishing endometrial glands
Copyright policy )Centromere protein b-null mice display decreasing reproductive performance through successive generations of breeding due to diminishing endometrial glands
Centromere protein B is a highly conserved constitutive protein found at centromeres. Gene knockout studies in mice have unexpectedly identifiedCenpbas a candidate gene involved in uterine function. The present study further explores the role ofCenpbin mice by intermatingCenpb-null mice over several generations. Breeding studies and analysis of uterine tissue indicate thatCenpb-null mice lose reproductive fitness over a number of generations due to a significant reduction in endometrial glands. These results suggest thatCenpbmay play an important function in the short- and long-term maintenance of uterine integrity.
- Royal Children's Hospital Australia
- University of Melbourne Australia
- Murdoch Children's Research Institute Australia
Male, Mice, Knockout, Chromosomal Proteins, Non-Histone, Reproduction, Ovary, Genomics, Organ Size, Breeding, Autoantigens, DNA-Binding Proteins, Mice, Inbred C57BL, Endometrium, Mice, Animals, Female, Centromere Protein B
Male, Mice, Knockout, Chromosomal Proteins, Non-Histone, Reproduction, Ovary, Genomics, Organ Size, Breeding, Autoantigens, DNA-Binding Proteins, Mice, Inbred C57BL, Endometrium, Mice, Animals, Female, Centromere Protein B
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