Suppressed clinical experimental autoimmune myasthenia gravis in bm12 mice is linked to reduced intracellular calcium mobilization and IL-10 and IFN-γ release by acetylcholine receptor-specific T cells
Copyright policy )Suppressed clinical experimental autoimmune myasthenia gravis in bm12 mice is linked to reduced intracellular calcium mobilization and IL-10 and IFN-γ release by acetylcholine receptor-specific T cells
Class II MHC mutant bm12 mice have an increased resistance to experimental autoimmune myasthenia gravis (EAMG) compared to C57BL/6 mice. In vitro, this relative resistance was mainly associated with a reduced cytokine response to acetylcholine receptor (AChR) and its dominant pathogenic peptide alpha 146-162, whereas the response to the epitope alpha 111-126 remained intact. Calcium mobilization after stimulation of AChR-immune T cells with AChR or alpha 146-162 peptide, but not alpha 111-126 peptide, was decreased in bm12 compared to C57BL/6. Thus, the reduced incidence of clinical EAMG in bm12 is linked to lower IFN-gamma and IL-10 release, and intracellular calcium mobilization by alpha 146-162-specific T cells.
- University of Pennsylvania United States
- The University of Texas Medical Branch at Galveston United States
- National Institutes of Health United States
- National Cancer Institute United States
- University Medical Center United States
Intracellular Fluid, T-Lymphocytes, Histocompatibility Antigens Class II, Down-Regulation, Immunity, Innate, Peptide Fragments, Interleukin-10, Myasthenia Gravis, Autoimmune, Experimental, Mice, Inbred C57BL, Epitopes, Interferon-gamma, Mice, Mutation, Immune Tolerance, Animals, Calcium, Receptors, Cholinergic, Calcium Signaling, Spleen, Signal Transduction
Intracellular Fluid, T-Lymphocytes, Histocompatibility Antigens Class II, Down-Regulation, Immunity, Innate, Peptide Fragments, Interleukin-10, Myasthenia Gravis, Autoimmune, Experimental, Mice, Inbred C57BL, Epitopes, Interferon-gamma, Mice, Mutation, Immune Tolerance, Animals, Calcium, Receptors, Cholinergic, Calcium Signaling, Spleen, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).3 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!