Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma
Copyright policy )Oncogenic GNAQ mutations are not correlated with disease-free survival in uveal melanoma
Recently, oncogenic G protein alpha subunit q (GNAQ) mutations have been described in about 50% of uveal melanomas and in the blue nevi of the skin.GNAQ exon 5 was amplified from 75 ciliary body and choroidal melanoma DNAs and sequenced directly. GNAQ mutation status was correlated with disease-free survival (DFS), as well as other clinical and histopathological factors, and with chromosomal variations detected by FISH and CGH.Of the 75 tumour DNA samples analysed, 40 (53.3%) harboured oncogenic mutations in GNAQ codon 209. Univariate and multivariate analysis showed that GNAQ mutation status was not significantly correlated with DFS.The GNAQ mutation status is not suitable to predict DFS. However, the high frequency of GNAQ mutations may render it a promising target for therapeutic intervention.
- Erasmus University Rotterdam Netherlands
- Keck Hospital of USC United States
- University of California, San Francisco United States
- University of Tübingen Germany
- Erasmus University Medical Center Netherlands
Adult, Male, Uveal Neoplasms, Short Communication, Oncology and Carcinogenesis, 610, survival, Fluorescence, Disease-Free Survival, oncogenic mutation, Rare Diseases, SDG 3 - Good Health and Well-being, Genetics, 80 and over, Humans, Oncology & Carcinogenesis, Eye Disease and Disorders of Vision, EMC MGC-02-96-01, Melanoma, In Situ Hybridization, In Situ Hybridization, Fluorescence, Ophthalmology and Optometry, Cancer, Aged, Gq-G11, Aged, 80 and over, Comparative Genomic Hybridization, Biomedical and Clinical Sciences, Oncology and carcinogenesis, EMC OR-01-60-01, Middle Aged, GTP-Binding Protein alpha Subunits, Multivariate Analysis, Mutation, Public Health and Health Services, GTP-Binding Protein alpha Subunits, Gq-G11, Female, uveal melanoma, Biotechnology, Follow-Up Studies
Adult, Male, Uveal Neoplasms, Short Communication, Oncology and Carcinogenesis, 610, survival, Fluorescence, Disease-Free Survival, oncogenic mutation, Rare Diseases, SDG 3 - Good Health and Well-being, Genetics, 80 and over, Humans, Oncology & Carcinogenesis, Eye Disease and Disorders of Vision, EMC MGC-02-96-01, Melanoma, In Situ Hybridization, In Situ Hybridization, Fluorescence, Ophthalmology and Optometry, Cancer, Aged, Gq-G11, Aged, 80 and over, Comparative Genomic Hybridization, Biomedical and Clinical Sciences, Oncology and carcinogenesis, EMC OR-01-60-01, Middle Aged, GTP-Binding Protein alpha Subunits, Multivariate Analysis, Mutation, Public Health and Health Services, GTP-Binding Protein alpha Subunits, Gq-G11, Female, uveal melanoma, Biotechnology, Follow-Up Studies
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