Differential Roles for IL-15R α-Chain in NK Cell Development and Ly-49 Induction
Copyright policy )Differential Roles for IL-15R α-Chain in NK Cell Development and Ly-49 Induction
AbstractIL-15Rα-deficient (IL-15Rα−/−) mice lack NK cells. However, when bone marrow (BM) progenitors from IL-15Rα−/− mice were cultured with IL-7, stem cell factor and flt3 ligand, followed by IL-15, they were able to differentiate into functional NK cells, indicating that IL-15Rα is not critical for NK cell development. Whereas NK cells generated in vitro from IL-15Rα−/− BM progenitors expressed CD94/NKG2, they failed to express Ly-49 receptors. In keeping with this, when IL-15Rα−/− BM cells were transferred into wild type recipients, they gave rise to NK cells in vivo, but with greatly reduced expression of Ly-49 receptors. Furthermore, the small numbers of NK cells found in IL-15−/− as well as IL-15Rα−/− but not flt3 ligand−/− mice expressed much lower levels of Ly-49 receptors than those from wild type mice. These results indicate a novel role for IL-15Rα-chain in Ly-49 induction on developing NK cells.
- University of Chicago United States
Interleukin-15, Mice, Knockout, Receptors, Interleukin-15, Down-Regulation, Bone Marrow Cells, Cell Differentiation, Receptors, Interleukin-2, Hematopoietic Stem Cells, Killer Cells, Natural, Mice, Inbred C57BL, Mice, Protein Subunits, Radiation Chimera, Animals, Antigens, Ly, Lectins, C-Type, Receptors, Immunologic, Cells, Cultured, Bone Marrow Transplantation, Receptors, NK Cell Lectin-Like
Interleukin-15, Mice, Knockout, Receptors, Interleukin-15, Down-Regulation, Bone Marrow Cells, Cell Differentiation, Receptors, Interleukin-2, Hematopoietic Stem Cells, Killer Cells, Natural, Mice, Inbred C57BL, Mice, Protein Subunits, Radiation Chimera, Animals, Antigens, Ly, Lectins, C-Type, Receptors, Immunologic, Cells, Cultured, Bone Marrow Transplantation, Receptors, NK Cell Lectin-Like
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