Structure-guided discovery of a single-domain antibody agonist against human apelin receptor
Copyright policy ) Yanbin Ma; Yao Ding; Xianqiang Song; Xiaochuan Ma; Xun Li; Ning Zhang; Yunpeng Song; Yaping Sun; Yuqing Shen; Wenge Zhong; Liaoyuan A. Hu; Yingli Ma; Mei-Yun Zhang;
Structure-guided discovery of a single-domain antibody agonist against human apelin receptor
We converted a potent antagonistic sdAb JN241 to an agonistic sdAb JN241-9 to human APJ by structure-guided rational design.
- Amgen (United States) United States
- Amgen (China) China (People's Republic of)
Apelin Receptors, Binding Sites, Molecular Conformation, Quantitative Structure-Activity Relationship, Molecular Dynamics Simulation, Single-Domain Antibodies, Molecular Docking Simulation, Drug Design, Drug Discovery, Animals, Humans, Research Articles, Protein Binding
Apelin Receptors, Binding Sites, Molecular Conformation, Quantitative Structure-Activity Relationship, Molecular Dynamics Simulation, Single-Domain Antibodies, Molecular Docking Simulation, Drug Design, Drug Discovery, Animals, Humans, Research Articles, Protein Binding
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).78 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
citations
Citations provided by BIP!
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
Popularity provided by BIP! 78
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