A dual function of NKG2D ligands in NK‐cell activation
Copyright policy )A dual function of NKG2D ligands in NK‐cell activation
NK‐cell killing requires both the expression of activating receptor ligands and low MHC class I expression by target cells. Here we demonstrate that the expression of any of the murine ligands for the NK‐cell activating receptor NKG2D results in a concomitant reduction in MHC class I expression. We show this both in tumor cell lines and in vivo. NK‐cell lysis is enhanced by the decrease in MHC class I expression, suggesting the change is biologically relevant. These results demonstrate that NKG2D ligand expression on target cells not only allows for activating receptor recognition, but also actively reduces expression of the inhibitory ligand, MHC class I, leading to enhanced recognition and killing by NK cells.
- University of Mary United States
- SVEUCILISTE U ZAGREBU FAKULTET ELEKTROTEHNIKE I RACUNARSTVA Croatia
- Howard Hughes Medical Institute United States
- Washington University in St. Louis United States
- University of Rijeka, Faculty of Medicine Croatia
Nucleocytoplasmic Transport Proteins, Histocompatibility Antigens Class I, NK cells, NKG2D ligands, Ligands, Lymphocyte Activation, NKG2D, NKG2D; NK cells; NKG2D ligands, Killer Cells, Natural, Mice, Inbred C57BL, Mice, Nuclear Matrix-Associated Proteins, NK Cell Lectin-Like Receptor Subfamily K, Cell Line, Tumor, Animals
Nucleocytoplasmic Transport Proteins, Histocompatibility Antigens Class I, NK cells, NKG2D ligands, Ligands, Lymphocyte Activation, NKG2D, NKG2D; NK cells; NKG2D ligands, Killer Cells, Natural, Mice, Inbred C57BL, Mice, Nuclear Matrix-Associated Proteins, NK Cell Lectin-Like Receptor Subfamily K, Cell Line, Tumor, Animals
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