PCR-based screening of MNS glycophorin variants in patients suspected of having anti-Mia
Copyright policy )PCR-based screening of MNS glycophorin variants in patients suspected of having anti-Mia
Background:MNS glycophorin variants such as glycoprotein (GP.) Mur, GP.Hop, GP.Bun, GP.HF, GP.Hut, and GP.Vw are known to carry multiple antigens, including Mia (MNS7). In East and Southeast Asians, an antibody to Mia is not only commonly found, but also clinically significant. Purpose and Methods: In this study, deoxyribonucleic acid (DNA) samples from 47 patients suspected of having anti-Mia by serological screening were genotyped for GP.Mur, GP.Hop, GP.Bun, GP.HF, GP.Hut, and GP.Vw variants using polymerase chain reaction (PCR) assay. Results: All patients were found to be negative for the presence of Mia-positive glycophorin variants. Conclusions: The presence of anti-Mia cannot be excluded in patients studied, as genotyping shows that Mia-positive MNS glycophorin variants are not present. Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 432-437
- Chinese Academy of Sciences China (People's Republic of)
- Hospital Universiti Sains Malaysia Malaysia
- Chinese Academy of Science (中国科学院) China (People's Republic of)
- Universiti Sains Malaysia Malaysia
- Chinese Academy of Science China (People's Republic of)
Genotyping, Genotype, Physiology, Immunology, Mechanosensitive Ion Channels in Physiology and Disease, Gene, Diseases Related to Blood Group Variants, Biochemistry, Genetics and Molecular Biology, Phenotype Analysis, Health Sciences, Genetics, Biology, Antibody, FOS: Clinical medicine, Life Sciences, Hematology, Standards and Guidelines for Genetic Variant Interpretation, Polymerase chain reaction, Serology, FOS: Biological sciences, Antigen, Medicine, Glycophorin
Genotyping, Genotype, Physiology, Immunology, Mechanosensitive Ion Channels in Physiology and Disease, Gene, Diseases Related to Blood Group Variants, Biochemistry, Genetics and Molecular Biology, Phenotype Analysis, Health Sciences, Genetics, Biology, Antibody, FOS: Clinical medicine, Life Sciences, Hematology, Standards and Guidelines for Genetic Variant Interpretation, Polymerase chain reaction, Serology, FOS: Biological sciences, Antigen, Medicine, Glycophorin
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