Pre‐mRNA 3′‐end processing complex assembly and function
Copyright policy )Pre‐mRNA 3′‐end processing complex assembly and function
AbstractThe 3′‐ends of almost all eukaryotic mRNAs are formed in a two‐step process, an endonucleolytic cleavage followed by polyadenylation (the addition of a poly‐adenosine or poly(A) tail). These reactions take place in the pre‐mRNA 3′ processing complex, a macromolecular machinery that consists of more than 20 proteins. A general framework for how the pre‐mRNA 3′ processing complex assembles and functions has emerged from extensive studies over the past several decades using biochemical, genetic, computational, and structural approaches. In this article, we review what we have learned about this important cellular machine and discuss the remaining questions and future challenges. WIREs RNA 2011 2 321–335 DOI: 10.1002/wrna.54This article is categorized under: RNA Processing > 3' End Processing
- University of California, Irvine United States
mRNA Cleavage and Polyadenylation Factors, Macromolecular Substances, Polynucleotide Adenylyltransferase, RNA-Binding Proteins, RNA 3' Polyadenylation Signals, DNA-Directed RNA Polymerases, Saccharomyces cerevisiae, Plants, Models, Biological, Poly(A)-Binding Proteins, RNA Precursors, Animals, Humans, Protein Interaction Domains and Motifs, RNA 3' End Processing
mRNA Cleavage and Polyadenylation Factors, Macromolecular Substances, Polynucleotide Adenylyltransferase, RNA-Binding Proteins, RNA 3' Polyadenylation Signals, DNA-Directed RNA Polymerases, Saccharomyces cerevisiae, Plants, Models, Biological, Poly(A)-Binding Proteins, RNA Precursors, Animals, Humans, Protein Interaction Domains and Motifs, RNA 3' End Processing
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