Characterization of a severe parenchymal phenotype of experimental autoimmune encephalomyelitis in (C57BL6xB10.PL)F1 mice
Copyright policy )Characterization of a severe parenchymal phenotype of experimental autoimmune encephalomyelitis in (C57BL6xB10.PL)F1 mice
We here describe a novel CD4 T cell adoptive transfer model of severe experimental autoimmune encephalomyelitis in (C57BL6xB10.PL)F1 mice. This FI cross developed severe disease characterized by extensive parenchymal spinal cord and brain periventricular white matter infiltrates. In contrast, B10.PL mice developed mild disease characterized by meningeal predominant infiltrates. As determined by cDNA microarray and quantitative real time PCR expression analysis, histologic and flow cytometry analysis of inflammatory infiltrates, and attenuation of disease in class I-deficient and CD8-depleted F1 mice; this severe disease phenotype appears to be regulated by CNS infiltration of CD8 T lymphocytes early in the disease course.
- Yale University United States
CD4-Positive T-Lymphocytes, Encephalomyelitis, Autoimmune, Experimental, Reverse Transcriptase Polymerase Chain Reaction, CD8 Antigens, Brain, Macrophage-1 Antigen, Mice, Transgenic, Myelin Basic Protein, CD8-Positive T-Lymphocytes, Adoptive Transfer, Immunophenotyping, Mice, Inbred C57BL, Disease Models, Animal, Mice, Meninges, Gene Expression Regulation, Spinal Cord, Animals, RNA, Messenger, Oligonucleotide Array Sequence Analysis
CD4-Positive T-Lymphocytes, Encephalomyelitis, Autoimmune, Experimental, Reverse Transcriptase Polymerase Chain Reaction, CD8 Antigens, Brain, Macrophage-1 Antigen, Mice, Transgenic, Myelin Basic Protein, CD8-Positive T-Lymphocytes, Adoptive Transfer, Immunophenotyping, Mice, Inbred C57BL, Disease Models, Animal, Mice, Meninges, Gene Expression Regulation, Spinal Cord, Animals, RNA, Messenger, Oligonucleotide Array Sequence Analysis
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