Single‐nucleotide polymorphisms in the 17β‐hydroxysteroid dehydrogenase genes might predict the risk of side‐effects of estramustine phosphate sodium in prostate cancer patients
Copyright policy )Single‐nucleotide polymorphisms in the 17β‐hydroxysteroid dehydrogenase genes might predict the risk of side‐effects of estramustine phosphate sodium in prostate cancer patients
AbstractBackground: Estramustine phosphate sodium (EMP) frequently causes side‐effects such as gastrointestinal discomfort, nausea, and edema in extremities. We analyzed single nucleotide polymorphisms (SNP) in the 17β‐hydroxysteroid dehydrogenase (HSD17B) genes, which are involved in the metabolism of EMP, to predict the risk of EMP side‐effects in prostate cancer patients.Methods: We performed genotyping of SNP in the HSD17B genes of 44 Japanese patients with newly diagnosed prostate cancer. The association of SNP and individual EMP side‐effects was evaluated.Results: Peripheral edema occurred more frequently in patients with C/C genotype of IMS‐JST123219 than in those with C/G genotype (OR: 5.47, 95% CI: 1.27–23.64). Haplotype analysis showed that appetite loss was associated with the G allele of IMS‐JST123219 and the T allele of IMS‐JST123218 (OR: 9.13, 95% CI: 1.15–72.76).Conclusions: These preliminary data demonstrated that analyses of SNP in the HSD17B genes might predict the occurrence of side‐effects from EMP.
Aged, 80 and over, Male, 17-Hydroxysteroid Dehydrogenases, Antineoplastic Agents, Hormonal, Genotype, Appetite, Prostatic Neoplasms, Middle Aged, Polymorphism, Single Nucleotide, Gene Frequency, Haplotypes, Risk Factors, Estramustine, Edema, Humans, Aged
Aged, 80 and over, Male, 17-Hydroxysteroid Dehydrogenases, Antineoplastic Agents, Hormonal, Genotype, Appetite, Prostatic Neoplasms, Middle Aged, Polymorphism, Single Nucleotide, Gene Frequency, Haplotypes, Risk Factors, Estramustine, Edema, Humans, Aged
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