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Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure–activity relationship, activity profile, mode of action, and molecular docking

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2022 English Publisher:Royal Society of Chemistry (RSC)Journal:RSC Advances, volume 12, pages 20,507-20,518 (eissn: 2046-2069,

Authors: Hatice Yıldırım; Mahmut Yıldız; Nilüfer Bayrak; Emel Mataracı-Kara; Berna Özbek-Çelik; Masami Otsuka; Mikako Fujita; +2 Authors

doi: 10.1039/d2ra02136f

pmid: 35919160

pmc: PMC9284347

Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure–activity relationship, activity profile, mode of action, and molecular docking

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Abstract

In an attempt to develop effective and potentially active antibacterial and/or antifungal agents, we designed, synthesized, and characterized thiolated CoQ analogs (CoQ1–8) with an extensive antimicrobial study.

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Chemistry

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Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure–activity relationship, activity profile, mode of action, and molecular docking

Natural-product-inspired design and synthesis of thiolated coenzyme Q analogs as promising agents against Gram-positive bacterial strains: insights into structure–activity relationship, activity profile, mode of action, and molecular docking

1 Research products, page 1 of 1

3G75