Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: implication for prostate cancer risk
Copyright policy )Serum sex steroid hormone levels and polymorphisms of CYP17 and SRD5A2: implication for prostate cancer risk
Polymorphism of the steroid hormone-related genes might affect life-long androgen exposure, thus altering a risk of prostate cancer incidence. To evaluate the effect of the polymorphisms of CYP17 and SRD5A2 on serum steroid hormone levels, the 164 male Japanese cohort were tested for serum hormone levels and the genotype of the polymorphisms of CYP17 (T-C base substitution in the promoter region) and SRD5A2 (V89L). The linear trends across the CYP17 genotypes in serum-free testosterone and androstenedione levels were found, suggesting the importance of the polymorphism of CYP17 in determining the circulating androgen levels.
- Akita University Japan
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Androstenedione, Prostatic Neoplasms, Steroid 17-alpha-Hydroxylase, DNA, Neoplasm, Middle Aged, Cohort Studies, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Japan, Risk Factors, Androgens, Biomarkers, Tumor, Humans, Testosterone, Aged
Aged, 80 and over, Male, Polymorphism, Genetic, Genotype, Androstenedione, Prostatic Neoplasms, Steroid 17-alpha-Hydroxylase, DNA, Neoplasm, Middle Aged, Cohort Studies, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Japan, Risk Factors, Androgens, Biomarkers, Tumor, Humans, Testosterone, Aged
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).17 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!