Allelic distribution of CTG18.1 in Caucasian populations: association studies in bipolar disorder, schizophrenia, and ataxia
Copyright policy )Allelic distribution of CTG18.1 in Caucasian populations: association studies in bipolar disorder, schizophrenia, and ataxia
CTG18.1 is a highly polymorphic and unstable CTG repeat within an intron of the SEF2-1 gene. We tested the CTG18.1 repeat length in affective disorder, schizophrenia, and nonspecific ataxia; these diseases all have shown clinical evidence for anticipation. There was no difference in the allele frequencies comparing the controls and disease groups. The most common allele contains 11 CAGs (35%) followed by alleles with 14-17 CAGs (35%). There was no difference in the distribution of the alleles in the cases vs controls for ataxia (P = 0.11), affective disorders (P = 0.21), or schizophrenia (P = 0.26). The frequency of unstable CTG18.1 alleles was approximately 3% in a population of N. European descent and is not related to the phenotypes tested.
- University of Chicago United States
- Johns Hopkins University United States
- Johns Hopkins Medicine United States
- University of Rostock Germany
- University of Sarajevo Bosnia and Herzegovina
Male, Bipolar Disorder, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Introns, Linkage Disequilibrium, White People, DNA-Binding Proteins, Transcription Factor 4, Gene Frequency, Trinucleotide Repeats, Schizophrenia, Trans-Activators, Humans, Ataxia, Female, TCF Transcription Factors, Transcription Factor 7-Like 2 Protein, Alleles, Transcription Factors
Male, Bipolar Disorder, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Introns, Linkage Disequilibrium, White People, DNA-Binding Proteins, Transcription Factor 4, Gene Frequency, Trinucleotide Repeats, Schizophrenia, Trans-Activators, Humans, Ataxia, Female, TCF Transcription Factors, Transcription Factor 7-Like 2 Protein, Alleles, Transcription Factors
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