Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice
Copyright policy )Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice
The polymorphism of aldehyde dehydrogenase 2 (ALDH2), denoted ALDH2*2, is very common in East Asian countries, and the mutated ALDH2 protein derived from ALDH2*2 lacks the ability of acetaldehyde metabolization. Our aim was to determine the consequences of the ALDH2 polymorphism on ethanol-administered liver tissue.Aldh2+/+, +/-, and -/- mice were fed with ethanol solution and standard hard feed for 5 weeks.The serum alanine aminotransferase (ALT) level in the Aldh2-/- mice clearly decreased upon ethanol feeding, in contrast to Aldh2+/+ mice, in which the ALT level was unchanged. The levels of malondialdehyde, phospho extracellular signal-regulated kinase 2, and tumor necrosis factor-alpha in the liver tissue all correlated with the ALT level.These findings suggest that ethanol intake in the presence of inactive ALDH2 decreases the serum ALT level following a decrease in oxidative stress and tumor necrosis factor-alpha secretion.
- Kyushu University Japan
- Saga University Japan
- Saga Medical School Hospital Japan
- University of Occupational and Environmental Health Japan Japan
- Saga Group United Kingdom
Male, Mice, Knockout, Ethanol, Tumor Necrosis Factor-alpha, Aldehyde Dehydrogenase, Mitochondrial, Alanine Transaminase, Acetaldehyde, Aldehyde Dehydrogenase, Animal Feed, Models, Biological, Mice, Inbred C57BL, Mice, Oxidative Stress, Liver, Animals, Female
Male, Mice, Knockout, Ethanol, Tumor Necrosis Factor-alpha, Aldehyde Dehydrogenase, Mitochondrial, Alanine Transaminase, Acetaldehyde, Aldehyde Dehydrogenase, Animal Feed, Models, Biological, Mice, Inbred C57BL, Mice, Oxidative Stress, Liver, Animals, Female
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