Glucocorticoid hormones are known to activate cellular responses through GR (Glucocorticoid Receptor) mediated transcriptional regulation of target genes. After hormone stimulation, GR binds to GBR (GR Binding Regions) in the Genome and subsequently recruits coregulators which can either stimulate or inhibit the transcription in a gene specific manner. Our focus is on the coregulators, H3K9 Histone Methyl-Transferases G9a and GLP (G9a Like Protein). G9a/GLP can act gene specifically as coactivator or corepressor. Indeed, G9a/GLP methylates H3K9, a well-known repressive mark. Dr. Stallcup?s laboratory demonstrated that G9a/GLP can also act as coactivator of GR. This coactivator function is controlled by a Post Translational Modification Switch in their N-Terminal Transcriptional Activation Domains. Auto-Methylation at a specific Lysine in that domain enables its coactivator function