BindingDB Entry 50043248: 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes.

Name: BindingDB Entry 50043248: 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes.
Creator: BindingDB
Keywords: 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) and 11-beta-hydroxysteroid dehydrogenase 1, Sanofi Deutschland GmbH, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2014 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2bv7j2h

BindingDB Entry 50043248: 1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes.

- Summary
- Subjects
- Related research
  (21)
- Metrics

tips_and_updates
Recommended

Abstract

Small molecule binding data for protein 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) and 11-beta-hydroxysteroid dehydrogenase 1, Uniprot P16232, P28845, and P50172

Keywords

11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) and 11-beta-hydroxysteroid dehydrogenase 1, Sanofi Deutschland GmbH, Affinity

21 Research products, page 1 of 3

BindingDB Entry 50040742: Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).
2013IsAmongTopNSimilarDocuments
Higher 11-beta-hydroxysteroid dehydrogenase type I gene expression in white adipose tissue in male than female rats.
2012IsAmongTopNSimilarDocuments
BindingDB Entry 50018414: Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.
2009IsAmongTopNSimilarDocuments
BindingDB Entry 3391: Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
2009IsAmongTopNSimilarDocuments
BindingDB Entry 50026475: Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.
2010IsAmongTopNSimilarDocuments
BindingDB Entry 50033116: Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.
2011IsAmongTopNSimilarDocuments
BindingDB Entry 2600: 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice.
2008IsAmongTopNSimilarDocuments
BindingDB Entry 5865: Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
2013IsAmongTopNSimilarDocuments
BindingDB Entry 50032787: Synthesis and optimization of novel 4,4-disubstituted cyclohexylbenzamide derivatives as potent 11ß-HSD1 inhibitors.
2011IsAmongTopNSimilarDocuments
BindingDB Entry 1799: Therapeutic agent for pain
2019IsAmongTopNSimilarDocuments

chevron_left
1
2
3
chevron_right

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average