BindingDB Entry 50031961: Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.

Name: BindingDB Entry 50031961: Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.
Creator: BindingDB
Keywords: Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2) and poly-ADP-ribose polymerase 1 (PARP1), Johns Hopkins University Brain Science Institute, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2010 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2nv9jf0

BindingDB Entry 50031961: Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.

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Abstract

Small molecule binding data for protein Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2) and poly-ADP-ribose polymerase 1 (PARP1), Uniprot P09874 and Q9UGN5

Keywords

Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2) and poly-ADP-ribose polymerase 1 (PARP1), Johns Hopkins University Brain Science Institute, Affinity

16 Research products, page 1 of 2

Engineering the Substrate Specificity of ADP-Ribosyltransferases for Identifying Direct Protein Targets
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BindingDB Entry 50043358: Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.
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BindingDB Entry 50042982: Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
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BindingDB Entry 50043370: Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.
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BindingDB Entry 50043681: TBA
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Evolution of Poly(ADP-ribose) Polymerase-1 (PARP-1) Inhibitors. From Concept to Clinic
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BindingDB Entry 7027: 3-Oxo-2,3-dihydro-1H-indazole-4-carboxamide derivatives as PARP-1 inhibitors
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Characterization of the DNA dependent activation of human ARTD2/PARP2
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BindingDB Entry 8306: 3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors
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BindingDB Entry 50047033: Discovery and Characterization of (8S,9R)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent.
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