BindingDB Entry 3112: Discovery of thiophene inhibitors of polo-like kinase.

Name: BindingDB Entry 3112: Discovery of thiophene inhibitors of polo-like kinase.
Creator: BindingDB
Keywords: Serine/threonine-protein kinase PLK1 and Serine/threonine-protein kinase PLK3, GSK, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2009 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q26t0jzx

BindingDB Entry 3112: Discovery of thiophene inhibitors of polo-like kinase.

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Abstract

Small molecule binding data for protein Serine/threonine-protein kinase PLK1 and Serine/threonine-protein kinase PLK3, Uniprot P53350 and Q9H4B4

Keywords

Serine/threonine-protein kinase PLK1 and Serine/threonine-protein kinase PLK3, GSK, Affinity

15 Research products, page 1 of 2

BindingDB Entry 50001563: Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold.
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BindingDB Entry 50047589: Small molecules that target phosphorylation dependent protein-protein interaction.
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BindingDB Entry 50030554: Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.
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BindingDB Entry 3114: Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding.
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BindingDB Entry 50045401: Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors.
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BindingDB Entry 50009222: Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity.
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BindingDB Entry 50027415: Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.
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Discovery of thiophene inhibitors of polo-like kinase
2009IsDerivedFrom
BindingDB Entry 2974: Selectivity-determining residues in Plk1.
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BindingDB Entry 50025100: Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects.
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