BindingDB Entry 50031179: Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
BindingDB Entry 50031179: Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
Small molecule binding data for protein Phosphodiesterase 1, Phosphodiesterase 1A (PDE1A), Phosphodiesterase 1C (PDE1C), Phosphodiesterase 3 (PDE3), Phosphodiesterase 8, Voltage-gated potassium channel, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific 3',5'-cyclic phosphodiesterase 7B, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, and cGMP-specific 3',5'-cyclic phosphodiesterase, Uniprot O60658, O76074, O95263, P27815, P54750, Q01064, Q07343, Q08493, Q08499, Q12809, Q13370, Q14123, Q14432, and Q9NP56
Phosphodiesterase 1, Phosphodiesterase 1A (PDE1A), Phosphodiesterase 1C (PDE1C), Phosphodiesterase 3 (PDE3), Phosphodiesterase 8, Voltage-gated potassium channel, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific 3',5'-cyclic phosphodiesterase 7B, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, and cGMP-specific 3',5'-cyclic phosphodiesterase, Pfizer Global Research and Development, Affinity
Phosphodiesterase 1, Phosphodiesterase 1A (PDE1A), Phosphodiesterase 1C (PDE1C), Phosphodiesterase 3 (PDE3), Phosphodiesterase 8, Voltage-gated potassium channel, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific 3',5'-cyclic phosphodiesterase 7B, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, and cGMP-specific 3',5'-cyclic phosphodiesterase, Pfizer Global Research and Development, Affinity
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!