BindingDB Entry 50036953: Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

Name: BindingDB Entry 50036953: Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.
Creator: BindingDB
Keywords: ADAM17, Collagenase, Matrix Metalloproteinase-8 (MMP-8), Matrix metalloproteinase 15, Matrix metalloproteinase 16, Matrix metalloproteinase-1 (MMP1), Matrix metalloproteinase-14 (MMP14), Matrix metalloproteinase-7 (MMP7), and Stromelysin-1, DuPont Pharmaceuticals Company, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2012 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2fb53nr

BindingDB Entry 50036953: Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

- Summary
- Subjects
- Related research
  (13)
- Metrics

tips_and_updates
Recommended

Abstract

Small molecule binding data for protein ADAM17, Collagenase, Matrix Metalloproteinase-8 (MMP-8), Matrix metalloproteinase 15, Matrix metalloproteinase 16, Matrix metalloproteinase-1 (MMP1), Matrix metalloproteinase-14 (MMP14), Matrix metalloproteinase-7 (MMP7), and Stromelysin-1, Uniprot O77636, P03956, P08253, P08254, P09237, P14780, P22894, P45452, P50281, P51511, P51512, and P78536

Keywords

ADAM17, Collagenase, Matrix Metalloproteinase-8 (MMP-8), Matrix metalloproteinase 15, Matrix metalloproteinase 16, Matrix metalloproteinase-1 (MMP1), Matrix metalloproteinase-14 (MMP14), Matrix metalloproteinase-7 (MMP7), and Stromelysin-1, DuPont Pharmaceuticals Company, Affinity

13 Research products, page 1 of 2

BindingDB Entry 50046256: Discovery of novel, highly potent, and selective quinazoline-2-carboxamide-based matrix metalloproteinase (MMP)-13 inhibitors without a zinc binding group using a structure-based design approach.
2016IsAmongTopNSimilarDocuments
Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo
2001IsDerivedFrom
BindingDB Entry 50049066: Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach.
2019IsAmongTopNSimilarDocuments
BindingDB Entry 50034389: Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.
2012IsAmongTopNSimilarDocuments
BindingDB Entry 50037150: Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
2012IsAmongTopNSimilarDocuments
BindingDB Entry 50012584: Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.
2009IsAmongTopNSimilarDocuments
BindingDB Entry 50017559: Synthesis and structure-activity relationship of a novel, achiral series of TNF-alpha converting enzyme inhibitors.
2009IsAmongTopNSimilarDocuments
BindingDB Entry 50027780: Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates.
2010IsAmongTopNSimilarDocuments
BindingDB Entry 50013535: A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers.
2009IsAmongTopNSimilarDocuments
BindingDB Entry 50046297: SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.
2016IsAmongTopNSimilarDocuments

chevron_left
1
2
chevron_right

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average