BindingDB Entry 50040742: Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).

Name: BindingDB Entry 50040742: Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).
Creator: BindingDB
Keywords: 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-hydroxysteroid dehydrogenase 2, Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1), and Voltage-gated potassium channel, AstraZeneca, Affinity

Research datakeyboard_double_arrow_right Dataset 01 Jan 2013 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2wm1fjt

BindingDB Entry 50040742: Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).

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Abstract

Small molecule binding data for protein 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-hydroxysteroid dehydrogenase 2, Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1), and Voltage-gated potassium channel, Uniprot P14061, P16232, P28845, P50172, P80365, and Q12809

Keywords

11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-hydroxysteroid dehydrogenase 1, 11-beta-hydroxysteroid dehydrogenase 2, Estradiol 17-beta-dehydrogenase 1 (17beta-HSD1), and Voltage-gated potassium channel, AstraZeneca, Affinity

19 Research products, page 1 of 2

BindingDB Entry 50027771: Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model.
2010IsAmongTopNSimilarDocuments
BindingDB Entry 50018414: Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.
2009IsAmongTopNSimilarDocuments
BindingDB Entry 50033116: Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11ß-hydroxysteroid dehydrogenase 2 inhibitors.
2011IsAmongTopNSimilarDocuments
BindingDB Entry 50042936: Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
2014IsAmongTopNSimilarDocuments
Novel Acidic 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Inhibitor with Reduced Acyl Glucuronide Liability: The Discovery of 4-[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic Acid (AZD8329)
2012IsDerivedFrom
BindingDB Entry 50043187: Mono-carbonyl curcumin analogues as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.
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BindingDB Entry 50038789: Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
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BindingDB Entry 50044479: Discovery of camphor-derived pyrazolones as 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.
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BindingDB Entry 5865: Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors
2013IsAmongTopNSimilarDocuments
BindingDB Entry 50043078: Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension.
2014IsAmongTopNSimilarDocuments

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