BindingDB Entry 7641: 4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases

Name: BindingDB Entry 7641: 4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases
Creator: BindingDB
Keywords: ADAM17, Collagenase, Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), Matrix metalloproteinase-1 (MMP1), and Stromelysin-1, GALDERMA RESEARCH & DEVELOPMENT, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2017 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2tm78zs

BindingDB Entry 7641: 4-alkoxy-N-(2-hydroxycarbamoyl-2-piperidinyl-ethyl)-benzamide compounds as selective TACE-inhibitors for the treatment of inflammatory diseases

- Summary
- Subjects
- Related research
  (11)
- Metrics

tips_and_updates
Recommended

Abstract

Small molecule binding data for protein ADAM17, Collagenase, Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), Matrix metalloproteinase-1 (MMP1), and Stromelysin-1, Uniprot O14672, P03956, P08254, P14780, P78536, and Q13443

Keywords

ADAM17, Collagenase, Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9), Matrix metalloproteinase-1 (MMP1), and Stromelysin-1, GALDERMA RESEARCH & DEVELOPMENT, Affinity

11 Research products, page 1 of 2

BindingDB Entry 7111: N-[2-hydroxycarbamoyl-2-(piperazinyl) ethyl] benzamide compounds, their preparation and their use as TACE inhibitors
2016IsAmongTopNSimilarDocuments
BindingDB Entry 50033297: 2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors.
2011IsAmongTopNSimilarDocuments
BindingDB Entry 50047148: Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models.
2017IsAmongTopNSimilarDocuments
BindingDB Entry 50049210: Identification of novel TACE inhibitors compatible with topical application.
2019IsAmongTopNSimilarDocuments
BindingDB Entry 50031497: Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models.
2010IsAmongTopNSimilarDocuments
BindingDB Entry 50032629: Novel TNF-a converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases.
2011IsAmongTopNSimilarDocuments
BindingDB Entry 50030219: Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket.
2010IsAmongTopNSimilarDocuments
BindingDB Entry 50043441: TBA
2014IsAmongTopNSimilarDocuments
BindingDB Entry 50009909: Notch Antagonists: Potential Modulators of Cancer and Inflammatory Diseases.
2021IsAmongTopNSimilarDocuments
BindingDB Entry 8186: Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
2017IsAmongTopNSimilarDocuments

chevron_left
1
2
chevron_right

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average