BindingDB Entry 2974: Selectivity-determining residues in Plk1.

Name: BindingDB Entry 2974: Selectivity-determining residues in Plk1.
Creator: BindingDB
Keywords: Polo-Like Kinase 3, Serine/threonine-protein kinase PLK1, and Serine/threonine-protein kinase PLK2, Pfizer, Affinity

Research datakeyboard_double_arrow_right Dataset 01 Jan 2009 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2t151z8

BindingDB Entry 2974: Selectivity-determining residues in Plk1.

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Abstract

Small molecule binding data for protein Polo-Like Kinase 3, Serine/threonine-protein kinase PLK1, and Serine/threonine-protein kinase PLK2, Uniprot P53350, Q9H4B4, and Q9NYY3

Keywords

Polo-Like Kinase 3, Serine/threonine-protein kinase PLK1, and Serine/threonine-protein kinase PLK2, Pfizer, Affinity

21 Research products, page 1 of 3

BindingDB Entry 50014698: Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.
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BindingDB Entry 50030554: Imidazopyridine derivatives as potent and selective Polo-like kinase (PLK) inhibitors.
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BindingDB Entry 50045089: The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
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BindingDB Entry 3112: Discovery of thiophene inhibitors of polo-like kinase.
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BindingDB Entry 2809: Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors.
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BindingDB Entry 2866: Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
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BindingDB Entry 50043148: Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
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BindingDB Entry 50045401: Identification of indole-3-carboxylic acids as non-ATP-competitive Polo-like kinase 1 (Plk1) inhibitors.
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BindingDB Entry 50001563: Design, synthesis, and biological evaluation of novel highly selective polo-like kinase 2 inhibitors based on the tetrahydropteridin chemical scaffold.
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BindingDB Entry 2829: Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.
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