BindingDB Entry 50019128: Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.

Name: BindingDB Entry 50019128: Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Creator: BindingDB
Keywords: 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Abbott Laboratories, Affinity

Research datakeyboard_double_arrow_right Dataset 01 Jan 2009 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2z60nqn

BindingDB Entry 50019128: Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.

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Abstract

Small molecule binding data for protein 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Uniprot P16232, P28845, P50172, P50233, P51661, and P80365

Keywords

11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Abbott Laboratories, Affinity

17 Research products, page 1 of 2

BindingDB Entry 50001007: Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold.
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Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-N-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
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BindingDB Entry 50038912: 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.
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BindingDB Entry 50016846: Discovery of 4-heteroarylbicyclo[2.2.2]octyltriazoles as potent and selective inhibitors of 11beta-HSD1: novel therapeutic agents for the treatment of metabolic syndrome.
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BindingDB Entry 50039828: Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases.
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