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BindingDB Entry 50045052: Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation.

Authors: BindingDB;

BindingDB Entry 50045052: Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation.

Abstract

Small molecule binding data for protein 3-phosphoinositide dependent protein kinase-1, C-RAF, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Glycogen synthase kinase-3, Interleukin-1 receptor-associated kinase 4, JAK3/JAK1, LIM domain kinase 1, LIM domain kinase 2, MAP kinase ERK2, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 5, Protein kinase C alpha type, Rho-associated protein kinase, SRC, Serine/threonine-protein kinase 4 (STK4), Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase MST2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase SYK, VEGF-receptor 2 and tyrosine-protein kinase SRC, and Vascular endothelial growth factor receptor, Uniprot L7RSL3, O15530, O60674, O75116, O95819, O96017, P00519, P04049, P06239, P06493, P09769, P12931, P17252, P17948, P24941, P28482, P43405, P49841, P52333, P53667, P53671, Q12851, Q13043, Q13188, and Q9NWZ3

Keywords

3-phosphoinositide dependent protein kinase-1, C-RAF, Cyclin-dependent kinase 1, Cyclin-dependent kinase 2, Glycogen synthase kinase-3, Interleukin-1 receptor-associated kinase 4, JAK3/JAK1, LIM domain kinase 1, LIM domain kinase 2, MAP kinase ERK2, Mitogen-activated protein kinase 2, Mitogen-activated protein kinase kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 5, Protein kinase C alpha type, Rho-associated protein kinase, SRC, Serine/threonine-protein kinase 4 (STK4), Serine/threonine-protein kinase Chk2, Serine/threonine-protein kinase MST2, Tyrosine-protein kinase ABL1, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase SYK, VEGF-receptor 2 and tyrosine-protein kinase SRC, and Vascular endothelial growth factor receptor, Lexicon Pharmaceuticals, Affinity

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
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Average