BindingDB Entry 50047288: Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.

Name: BindingDB Entry 50047288: Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.
Creator: BindingDB
Keywords: 1,3-beta-glucan synthase component GLS2, Ephrin receptor, Epidermal growth factor receptor, Insulin receptor, Insulin-like growth factor I receptor, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, PI3-kinase subunit alpha, PI3-kinase subunit beta, SRC, Tyrosine-protein kinase JAK1, and Vascular endothelial growth factor receptor 2, Novartis Institutes for Biomedical Research, Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2017 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q21z469m

BindingDB Entry 50047288: Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.

- Summary
- Subjects
- Related research
  (7)
- Metrics

tips_and_updates
Recommended

Abstract

Small molecule binding data for protein 1,3-beta-glucan synthase component GLS2, Ephrin receptor, Epidermal growth factor receptor, Insulin receptor, Insulin-like growth factor I receptor, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, PI3-kinase subunit alpha, PI3-kinase subunit beta, SRC, Tyrosine-protein kinase JAK1, and Vascular endothelial growth factor receptor 2, Uniprot P00533, P06213, P06239, P07949, P08069, P23458, P35968, P40989, P42336, P42338, P54760, and Q541P7

Keywords

1,3-beta-glucan synthase component GLS2, Ephrin receptor, Epidermal growth factor receptor, Insulin receptor, Insulin-like growth factor I receptor, Kinesin-1 heavy chain/ Tyrosine-protein kinase receptor RET, PI3-kinase subunit alpha, PI3-kinase subunit beta, SRC, Tyrosine-protein kinase JAK1, and Vascular endothelial growth factor receptor 2, Novartis Institutes for Biomedical Research, Affinity

7 Research products, page 1 of 1

BindingDB Entry 2846: Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.
2008IsAmongTopNSimilarDocuments
BindingDB Entry 50045057: Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases.
2016IsAmongTopNSimilarDocuments
Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors
2016IsDerivedFrom
BindingDB Entry 50047215: Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation.
2017IsAmongTopNSimilarDocuments
BindingDB Entry 50032427: Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors.
2011IsAmongTopNSimilarDocuments
BindingDB Entry 50040352: Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.
2013IsAmongTopNSimilarDocuments
BindingDB Entry 50045809: Current kinase inhibitors cover a tiny fraction of fragment space.
2016IsAmongTopNSimilarDocuments

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	0
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average

BindingDB Entry 50047288: Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.

BindingDB Entry 50047288: Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.

7 Research products, page 1 of 1

BindingDB Entry 2846: Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.

BindingDB Entry 50045057: Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases.

Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors

BindingDB Entry 50047215: Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation.

BindingDB Entry 50032427: Inhibitors of the tyrosine kinase EphB4. Part 3: identification of non-benzodioxole-based kinase inhibitors.

BindingDB Entry 50040352: Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics.

BindingDB Entry 50045809: Current kinase inhibitors cover a tiny fraction of fragment space.