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Successful treatment of Balamuthia mandrillaris granulomatous amoebic encephalitis with the novel agent nitroxoline

Name: Successful treatment of Balamuthia mandrillaris granulomatous amoebic encephalitis with the novel agent nitroxoline
Keywords: 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 08 Aug 2022Publisher:Springer Science and Business Media LLC

Authors: Natasha Spottiswoode; Douglas Pet; Annie Kim; Katherine Gruenberg; Maulik Shah; Amrutha Ramachandran; Matthew Laurie; +11 Authors

doi: 10.21203/rs.3.rs-1910386/v1

Successful treatment of Balamuthia mandrillaris granulomatous amoebic encephalitis with the novel agent nitroxoline

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Abstract

Abstract This case report describes a survivor of Balamuthia mandrillaris granulomatous amoebic encephalitis (GAE) after treatment with the novel agent nitroxoline, a drug typically used to treat urinary tract infections. Nitroxoline was previously identified in a screen of US and European approved drugs for amoebicidal activity against this pathogen. We describe its successful first use in treating this rare and deadly disease.

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University of California San Francisco Medical Center
United States
University of California, San Francisco
United States

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