BindingDB Entry 50030759: Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.

Name: BindingDB Entry 50030759: Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Creator: BindingDB

Research datakeyboard_double_arrow_right Dataset 01 Jan 2010 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2h41rhv

BindingDB Entry 50030759: Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.

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Abstract

Small molecule binding data for protein Phosphodiesterase 1, Phosphodiesterase 11A (PDE11A), Phosphodiesterase 1A (PDE1A), Phosphodiesterase 1C (PDE1C), Phosphodiesterase 3 (PDE3), Phosphodiesterase 6A, Phosphodiesterase 7, Phosphodiesterase 8, Phosphodiesterase 9A, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific 3',5'-cyclic phosphodiesterase 7B, cGMP-dependent 3',5'-cyclic phosphodiesterase, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, and cGMP-specific 3',5'-cyclic phosphodiesterase, Uniprot O00408, O60658, O76074, O76083, O95263, P16499, P27815, P54750, Q01064, Q07343, Q08493, Q08499, Q13370, Q13946, Q14123, Q14432, Q9HCR9, and Q9NP56

Keywords

Phosphodiesterase 1, Phosphodiesterase 11A (PDE11A), Phosphodiesterase 1A (PDE1A), Phosphodiesterase 1C (PDE1C), Phosphodiesterase 3 (PDE3), Phosphodiesterase 6A, Phosphodiesterase 7, Phosphodiesterase 8, Phosphodiesterase 9A, cAMP-specific 3',5'-cyclic phosphodiesterase 4A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B, cAMP-specific 3',5'-cyclic phosphodiesterase 4C, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, cAMP-specific 3',5'-cyclic phosphodiesterase 7B, cGMP-dependent 3',5'-cyclic phosphodiesterase, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, and cGMP-specific 3',5'-cyclic phosphodiesterase, Pfizer Global Research and Development, Affinity

7 Research products, page 1 of 1

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BindingDB Entry 50030759: Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.

BindingDB Entry 50030759: Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.

7 Research products, page 1 of 1

BindingDB Entry 50028591: The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents.

BindingDB Entry 50017027: A new chemical tool for exploring the physiological function of the PDE2 isozyme.

BindingDB Entry 50037494: The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

BindingDB Entry 50006228: Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A).

BindingDB Entry 50031179: Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).

BindingDB Entry 50034110: Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.

Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: Discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one