BindingDB Entry 50033148: Bicyclo[2.2.2]octyltriazole inhibitors of 11ß-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.

Name: BindingDB Entry 50033148: Bicyclo[2.2.2]octyltriazole inhibitors of 11ß-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.
Creator: BindingDB
Keywords: 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Merck Research Laboratories, Affinity

Research datakeyboard_double_arrow_right Dataset 01 Jan 2011 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2qj7hmk

BindingDB Entry 50033148: Bicyclo[2.2.2]octyltriazole inhibitors of 11ß-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.

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Abstract

Small molecule binding data for protein 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Uniprot P28845, P50172, P51661, and P80365

Keywords

11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Merck Research Laboratories, Affinity

19 Research products, page 1 of 2

BindingDB Entry 50018196: Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements.
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BindingDB Entry 50018391: Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
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BindingDB Entry 50038912: 4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice.
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BindingDB Entry 50018206: Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors.
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BindingDB Entry 1733: Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
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BindingDB Entry 50001007: Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold.
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BindingDB Entry 50043169: Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.
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BindingDB Entry 50039721: Synthesis and evaluation of piperidine urea derivatives as efficacious 11ß-hydroxysteroid dehydrogenase type 1 inhibitors in diabetic ob/ob mice.
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BindingDB Entry 50045770: Hupehenols A-E, selective 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors from Viburnum hupehense.
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BindingDB Entry 50018609: Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
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