BindingDB Entry 50043169: Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.

Name: BindingDB Entry 50043169: Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.
Creator: BindingDB
Keywords: 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Chinese Academy of Sciences, Affinity

Research datakeyboard_double_arrow_right Dataset 01 Jan 2014 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2js9rv7

BindingDB Entry 50043169: Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.

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Abstract

Small molecule binding data for protein 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Uniprot P16232, P28845, P50172, P51661, and P80365

Keywords

11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1), 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2), 11-beta-hydroxysteroid dehydrogenase 1, and 11-beta-hydroxysteroid dehydrogenase 2, Chinese Academy of Sciences, Affinity

24 Research products, page 1 of 3

BindingDB Entry 50042936: Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
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BindingDB Entry 50039828: Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11ß-hydroxysteroid dehydrogenases.
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BindingDB Entry 2600: 2-Amino-1,3-thiazol-4(5H)-ones as Potent and Selective 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors: Enzyme-Ligand Co-Crystal Structure and Demonstration of Pharmacodynamic Effects in C57Bl/6 Mice.
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