BindingDB Entry 50042982: Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.

Name: BindingDB Entry 50042982: Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
Creator: BindingDB
Keywords: Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2), Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3), Poly [ADP-ribose] polymerase 6, and poly-ADP-ribose polymerase 1 (PARP1), Amgen Inc., Affinity, 3. Good health

Research datakeyboard_double_arrow_right Dataset 01 Jan 2014 English Publisher:BindingDB

Authors: BindingDB;

doi: 10.7270/q2qf8v74

BindingDB Entry 50042982: Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.

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Abstract

Small molecule binding data for protein Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2), Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3), Poly [ADP-ribose] polymerase 6, and poly-ADP-ribose polymerase 1 (PARP1), Uniprot P09874, Q2NL67, and Q9UGN5

Keywords

Human diphtheria toxin-like ADP-ribosyltransferase (ARTD2 or PARP2), Human diphtheria toxin-like ADP-ribosyltransferase (ARTD3 or PARP3), Poly [ADP-ribose] polymerase 6, and poly-ADP-ribose polymerase 1 (PARP1), Amgen Inc., Affinity

11 Research products, page 1 of 2

Discovery of Novel, Induced-Pocket Binding Oxazolidinones as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors
2013IsDerivedFrom
BindingDB Entry 8306: 3-phenyl-isoquinolin-1(2H)-one derivatives as PARP-1 inhibitors
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BindingDB Entry 5996: PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
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BindingDB Entry 50043640: Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
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BindingDB Entry 50031060: Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).
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BindingDB Entry 50042979: Fragment-based ligand design of novel potent inhibitors of tankyrases.
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