A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function.
Copyright policy )A cell cycle-dependent co-repressor mediates photoreceptor cell-specific nuclear receptor function.
Photoreceptor cell-specific nuclear receptor (PNR) (NR2E3) acts as a sequence-specific repressor that controls neuronal differentiation in the developing retina. We identified a novel PNR co-repressor, Ret-CoR, that is expressed in the developing retina and brain. Biochemical purification of Ret-CoR identified a multiprotein complex that included E2F/Myb-associated proteins, histone deacetylases (HDACs) and NCoR/HDAC complex-related components. Ret-CoR appeared to function as a platform protein for the complex, and interacted with PNR via two CoRNR motifs. Purified Ret-CoR complex exhibited HDAC activity, co-repressed PNR transrepression function in vitro, and co-repressed PNR function in PNR target gene promoters, presumably in the retinal progenitor cells. Notably, the appearance of Ret-CoR protein was cell-cycle-stage-dependent (from G1 to S). Therefore, Ret-CoR appears to act as a component of an HDAC co-repressor complex that supports PNR repression function in the developing retina, and may represent a co-regulator class that supports transcriptional regulator function via cell-cycle-dependent expression.
- University of Tokyo Japan
Cell Cycle, Gene Expression Regulation, Developmental, Receptors, Cytoplasmic and Nuclear, Cell Differentiation, Orphan Nuclear Receptors, Histone Deacetylases, Cell Line, Repressor Proteins, Mice, Multiprotein Complexes, Animals, Photoreceptor Cells, RNA Helicases, Cell Proliferation
Cell Cycle, Gene Expression Regulation, Developmental, Receptors, Cytoplasmic and Nuclear, Cell Differentiation, Orphan Nuclear Receptors, Histone Deacetylases, Cell Line, Repressor Proteins, Mice, Multiprotein Complexes, Animals, Photoreceptor Cells, RNA Helicases, Cell Proliferation
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