Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development.
Copyright policy Tissue-specific expression of the fos-related transcription factor fra-2 during mouse development.
The fra-2 gene is related to the proto-oncogene c-fos and encodes a member of the AP-1 transcription factor gene family. We have studied the expression of fra-2 during mouse embryonic development and compared it to the pattern of expression of other fos and jun family members. By in situ hybridization and immunohistochemical analysis we have shown fra-2 expression during late organogenesis. fra-2 transcripts are detected in several differentiating epithelia, developing cartilage and central nervous system. The pattern of fra-2 expression is distinct from that observed for other fos related genes, suggesting that fra-2 has a unique role in cellular differentiation during fetal development.
Central Nervous System, Base Sequence, Molecular Sequence Data, Gene Expression Regulation, Developmental, Fos-Related Antigen-2, Kidney, Immunohistochemistry, Bone and Bones, DNA-Binding Proteins, Embryonic and Fetal Development, Mice, Genes, jun, Adrenal Glands, Animals, Proto-Oncogene Proteins c-fos, DNA Primers, Transcription Factors
Central Nervous System, Base Sequence, Molecular Sequence Data, Gene Expression Regulation, Developmental, Fos-Related Antigen-2, Kidney, Immunohistochemistry, Bone and Bones, DNA-Binding Proteins, Embryonic and Fetal Development, Mice, Genes, jun, Adrenal Glands, Animals, Proto-Oncogene Proteins c-fos, DNA Primers, Transcription Factors
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