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[Significance of BCL6, MYC, P53 genes abnormalities for the prognosis of diffuse large B-cell lymphoma].

descriptionPublicationkeyboard_double_arrow_right Article 12 Feb 2015Journal:Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, volume 31 (issn: 1003-9406,

Authors: Panke, Gao; Qing, Li; Zhilin, Wang; Feng, Yan; Changqing, Lu; Xiangshan, Cao;

pmid: 25297597

[Significance of BCL6, MYC, P53 genes abnormalities for the prognosis of diffuse large B-cell lymphoma].

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Abstract

To explore the influence of BCL6, MYC, P53 genes abnormalities can on the prognosis of diffuse large B-cell lymphoma (DLBCL), and to identify independent prognostic factors for DLBCL in order to facilitate clinical prognosis and selection of stratification treatment for the patients.Sixty five newly diagnosed DLBCL pathological specimens were collected from 2009 to 2012. Interphase fluorescence in situ hybridization technique (I-FISH) was used to detect the status of BCL6, MYC and P53 genes. Clinical factors were combined with immunohistochemical results for multiple-factor survival analysis.The rates of BCL6 gene rearrangement, P53 gene deletion and MYC rearrangement were 21.5% (14/65), 35.4% (23/65) and 7.7% (5/65), respectively. BCL6 rearrangement group has obviously poorer overall survival (OS)(P< 0.05). COX proportional hazards model analysis showed that gender, BCL6 protein, BCL6 rearrangement, Ki67 index were prognosis factors independent of international prognostic index (IPI).BCL6 can influence the prognosis of patients with DLBCL at gene and protein levels and both are independent prognostic factors for DLBCL.

Related Organizations

First Affiliated Hospital of Soochow University
China (People's Republic of)
The First People's Hospital of Changzhou
China (People's Republic of)

Keywords

Adult, Aged, 80 and over, Gene Rearrangement, Male, Adolescent, Middle Aged, Prognosis, Survival Analysis, DNA-Binding Proteins, Proto-Oncogene Proteins c-myc, Survival Rate, Mutation, Proto-Oncogene Proteins c-bcl-6, Humans, Female, Lymphoma, Large B-Cell, Diffuse, Tumor Suppressor Protein p53, Gene Deletion, In Situ Hybridization, Fluorescence, Aged

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