Генетика

Article . 2012

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[SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].

Name: [SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].
Keywords: Transcriptional Activation, Ecdysone, Drosophila melanogaster, Gene Knockdown Techniques, Metamorphosis, Biological, Animals, Drosophila Proteins, Gene Expression Regulation, Developmental, Receptors, Cytoplasmic and Nuclear, Gene Regulatory Networks

descriptionPublicationkeyboard_double_arrow_right Article 18 Jun 2012 Russian Journal:Genetika, volume 48 (issn: 0016-6758,

Authors: N E, Vorob'eva; Iu V, Nikolenko; A N, Krasnov; Iu L, Kuz'mina; V V, Panov; E N, Nabirochkina; S G, Georgieva; +1 Authors

pmid: 22567850

[SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation].

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Abstract

The role of metazoan coactivator SAYP in nuclear receptor-driven gene activation in the ecdysone cascade of Drosophila is considered. SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex. The knockdown of SAYP leads to a decrease in the level of DHR3-activated transcription. DHR3 and SAYP interact during development and have multiple common targets across the genome.

Keywords

Transcriptional Activation, Ecdysone, Drosophila melanogaster, Gene Knockdown Techniques, Metamorphosis, Biological, Animals, Drosophila Proteins, Gene Expression Regulation, Developmental, Receptors, Cytoplasmic and Nuclear, Gene Regulatory Networks, Chromatin, Chromosomes, Transcription Factors

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