Kardiologiia

Article . 2011

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[Polymorphisms of 2B-adrenergic receptor and endothelial NO-Synthase genes in genesis of the hereditary sick sinus node syndrome].

descriptionPublicationkeyboard_double_arrow_right Article 18 Oct 2011 Russian Journal:Kardiologiia, volume 51 (issn: 0022-9040,

Authors: A A, Chernova; S Iu, Nikulina; V A, Shul'man; T S, Kukushkina; M I, Voevoda; V N, Maksimov;

pmid: 21878072

[Polymorphisms of 2B-adrenergic receptor and endothelial NO-Synthase genes in genesis of the hereditary sick sinus node syndrome].

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Abstract

In this work we have demonstrated for the first time on the clinico-genetic material association between hereditary sick sinus node syndrome (SSNS) ADRA2B and eNOS genes polymorphisms. We have established predominance of homozygote genotype of more rare DD allele in patients with SSNS (28%) compared with subjects of control group (8.99%). We have found predominance of heterozygote genotype 4a/4b in patients with SSNS compared with subjects of control group (41.8 and 25.39%, respectively). The data obtained allow to suggest that eNOS gene polymorphism might be associated with SSNS.

Keywords

Adult, Male, Sick Sinus Syndrome, Polymorphism, Genetic, Nitric Oxide Synthase Type III, Homozygote, Middle Aged, Electrocardiography, Receptors, Adrenergic, alpha-2, Humans, Female, Genetic Predisposition to Disease, Alleles, Sinoatrial Node

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