HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis.
Copyright policy )HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis.
To test whether the presence of RA associated HLA-DRB1*0101, HLA-DRB1*0401 and HLA-DRB1*0404 alleles individually influences anti-cyclic citrullinated peptide antibodies (anti-CCP) production.The frequency of anti-CCP antibodies was calculated in the sera of 260 RA patients expressing either two (double dose genotypes SE+/SE+), one (single dose genotypes SE+/SE-) or no RA associated HLA-DR alleles (SE-/SE-). Anti-CCP antibodies titers were also determined.RA associated HLA-DR alleles are not mandatory for production of anti-CCP. We found that 68% of SE-/SE- patients were anti-CCP positive. There was no significant difference in anti-CCP between SE negative patient (SE-/SE-) and patients expressing at least one SE (SE+/SE+ and SE+/SE-) (p=0.140). We observed no statistical difference in anti-CCP between RA patients expressing one or two SE (82% vs. 77%, p=0.577). Among SE+/SE-patients, HLA-DRB1*0404 was associated with anti-CCP with a statistically significant difference compared with SE negative patients (90% anti-CCP positive, p=0.02). HLA-DRB1*0404 was also associated with high titers of anti CCP with a statistically significant difference compared with HLA-DRB1*0401 and HLA-DRB1*0101 patients (p=0.025).The RA-associated HLA-DRB1*0404 allele was the most strongly associated with the presence of anti-CCP in RA sera. Moreover, HLA-DRB1*0404 patients had higher titers of anti CCP than patients with other RA associated HLA-DR alleles.
- Laboratoire Parole et Langage France
- French National Centre for Scientific Research France
- Umma University Kenya
- Inserm France
- Université Bourgogne Franche-Comté France
MESH: Scleroderma, Male, 610, MESH: Arthritis, Peptides, Cyclic, Arthritis, Rheumatoid, Rheumatoid, MESH: Autoantibodies, Humans, Autoantibodies, Cyclic, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, MESH: Humans, MESH: Middle Aged, Scleroderma, Systemic, MESH: Peptides, Systemic, Homozygote, HLA-DR Antigens, Middle Aged, MESH: HLA-DR Antigens, MESH: Case-Control Studies, MESH: Male, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Case-Control Studies, Female, MESH: Female, MESH: Homozygote, HLA-DRB1 Chains
MESH: Scleroderma, Male, 610, MESH: Arthritis, Peptides, Cyclic, Arthritis, Rheumatoid, Rheumatoid, MESH: Autoantibodies, Humans, Autoantibodies, Cyclic, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, MESH: Humans, MESH: Middle Aged, Scleroderma, Systemic, MESH: Peptides, Systemic, Homozygote, HLA-DR Antigens, Middle Aged, MESH: HLA-DR Antigens, MESH: Case-Control Studies, MESH: Male, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Case-Control Studies, Female, MESH: Female, MESH: Homozygote, HLA-DRB1 Chains
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