The Israel Medical Association journal

Article . 2002

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Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males.

Name: Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males.
Keywords: Adult, Male, Chi-Square Distribution, Polymorphism, Genetic, Myocardial Infarction, Platelet Membrane Glycoproteins, Middle Aged, Polymerase Chain Reaction, Logistic Models, Gene Frequency

descriptionPublicationkeyboard_double_arrow_right Article 11 Jul 2002 English Journal:The Israel Medical Association journal : IMAJ, volume 4 (issn: 1565-1088,

Authors: Nurit, Rosenberg; Ariella, Zivelin; Angela, Chetrit; Rima, Dardik; Nurit, Kornbrot; Dov, Freimark; Aida, Inbal;

pmid: 12073410

Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males.

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Abstract

Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPla/IIa, GPlb alpha, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction.To evaluate the risks exerted by each of the following polymorphisms in young males with AMI: HPA-1a/b in GPIIIa: 807C/T in GPIa; and HPA-2a/b. VNTR and Kozak C/T in GPlb alpha.We conducted a case-control study of 100 young males with first AMI before the age of 53 and 119 healthy controls of similar age. All subjects were tested for the above polymorphisms.The allele frequencies of each of the platelet polymorphisms were not significantly different between the young man with AMI and the controls. Smoking alone was associated with a 9.97-fold risk, and the presence of at least one metabolic risk factor resulted in a 2.57-fold risk of AMI.The platelet glycoproteins polymorphisms studied are not an independent risk factor for AMI.

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Sheba Medical Center
Israel

Keywords

Adult, Male, Chi-Square Distribution, Polymorphism, Genetic, Myocardial Infarction, Platelet Membrane Glycoproteins, Middle Aged, Polymerase Chain Reaction, Logistic Models, Gene Frequency, Risk Factors, Case-Control Studies, Humans, Alleles

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