Synthesis, structure and tumour necrosis factor-alpha production-enhancing properties of novel adamantylamino heterocyclic derivatives.
Copyright policy )Synthesis, structure and tumour necrosis factor-alpha production-enhancing properties of novel adamantylamino heterocyclic derivatives.
The synthesis of several adamantylated aminoheterocycles is reported. The attack of the adamantyl cation formed from 1-adamantanol in refluxing trifluoroacetic acid or induced by microwave irradiation provides adamantylamino-derivatives of respective heterocycles. Adamantylated heterocycles enhance the induction of tumour necrosis factor alpha (TNF-alpha) in genetically modified murine melanoma cells transduced with the gene for human TNF-alpha. Of the studied collection of adamantylated compounds, the most biologically active are 2-adamantylamino-6-methylpyridine and 2-adamantylamino4-methylpyrimidine. The crystal structure of 2-adamantylamino-6-methylpyridine is reported.
Models, Molecular, Tumor Necrosis Factor-alpha, Melanoma, Experimental, Adamantane, Antineoplastic Agents, Hydrogen Bonding, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Drug Design, Tumor Cells, Cultured, Animals, Humans, Indicators and Reagents, Adjuvants, Pharmaceutic
Models, Molecular, Tumor Necrosis Factor-alpha, Melanoma, Experimental, Adamantane, Antineoplastic Agents, Hydrogen Bonding, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Drug Design, Tumor Cells, Cultured, Animals, Humans, Indicators and Reagents, Adjuvants, Pharmaceutic
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