Plasma Levels of CXCL1 (GRO-α) and CXCL10 (IP-10) are Elevated in Type 2 Diabetic Patients: Evidence for the Involvement of Inflammation and Angiogenesis / Angiostasis in this Disease State
Copyright policy )Plasma Levels of CXCL1 (GRO-α) and CXCL10 (IP-10) are Elevated in Type 2 Diabetic Patients: Evidence for the Involvement of Inflammation and Angiogenesis / Angiostasis in this Disease State
Recent evidence has demonstrated that environment and genetic factors play pivotal roles in diabetes and its related complications. The significant contributory role of cytokines in pathogenesis of type 2 diabetes is also well documented. This study was aimed to examine and compare both CXCL1 (GRO-alpha) and CXCL10 (IP-10) circulating levels in type 2 diabetic patients and healthy controls.Peripheral blood samples were collected from 100 type 2 diabetic patients and 150 healthy controls. Circulating CXCL1 and CXCL10 levels were measured by ELISA.Elevated serum levels of both CXCL1 and CXCL10 were found in type 2 diabetic patients in comparison to controls.Elevated levels of CXCL1 and CXCL10 could possibly be used as a marker of inflammation and angiogenesis/angiostasis in type 2 diabetes.
- Rafsanjan University of Medical Sciences Iran (Islamic Republic of)
Adult, Inflammation, Male, Neovascularization, Pathologic, Chemokine CXCL1, Enzyme-Linked Immunosorbent Assay, Middle Aged, Chemokine CXCL10, Diabetes Mellitus, Type 2, Case-Control Studies, Humans, Female, Biomarkers
Adult, Inflammation, Male, Neovascularization, Pathologic, Chemokine CXCL1, Enzyme-Linked Immunosorbent Assay, Middle Aged, Chemokine CXCL10, Diabetes Mellitus, Type 2, Case-Control Studies, Humans, Female, Biomarkers
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