descriptionPublicationkeyboard_double_arrow_right Article 20 Jul 2012Publisher:Institute of Molecular Biology and Genetics (NAS Ukraine)Journal:Biopolymers and Cell, volume 28, pages 314-316 (issn: 0233-7657, eissn: 1993-6842,

Authors: Novokhatska, O.V.; Skrypkina, I.Ya.; Dergai, M.V.; Tsyba, L.O.; Rynditch, A.V.;

doi: 10.7124/bc.000067

RTK signaling regulator SPRY2 associates with endocytic adaptor ITSN1 in vivo

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Abstract

???????????????? ?????????????????????? ?????????????? ?????? ?????????????????????? ???????????????????????? (RTK) ?? ?????????????? ?????????? ??????????????????? ?? ??????????????????????, ???????? ?????????????? ???????????????? ?????????? ????????????????. ?????????????????????? 1 (ITSN1) ??? ???? ???????????????????? ???????????????????????????? ???????????????????? ??????????, ???? ???????? ???????????? ?? ???????????????? ???????????? ???????????? ??????????????-???????????????????????????????? ???????????????????? ???? ?????????????????? ???? ?????????????? ???????????????????? ?????????????????????????? ???? ???????? ????????????????????????. ????????. ?????????? ????????????, ?????? ???????????? ?????????????????????? ??????????????? ITSN1 ???? ???????????????? ???????????????? ?????????????? ?????? RTK. ????????????. ???????????????????????? ?????????????? ?????????????????? in silico, ?????????????????? ???????????? ?? ?????????????????????? ?????????????? ???? ???????????????? ???????????? ??????????????, ??????????????????????????????????, ???????????????????????? ????????????, ???????????? ?? GST, ???????????????????????????????????? ??????????????????????. ????????????????????. ???? ?????????????????? ?????????????? ??Scansite?? ?????????????????????? ??????????????????????? ???????????? SH3A ITSN1 ???? SPRY2. ?????? ???????????????????????????????????? ?????????????????????????? ???????? ?????????????????? ?????????? ?? GST SH3-???????????? ITSN1 ???????????????? ?? ?????????????? ?? ???????????????? Escherichia coli. ???????????????????????????? ???????????????????????? ????????????, ???????????? ?? GST, ??????????????????????, ???? ???????????? SH3A, N-SH3A (????????????-?????????????????????? ??????????????), SH3C ?? SH3E ITSN1 ???????????? ?????????????????????????? Flag-SPRY2 ?? ???????????? ????????????. ???????? ???????????????????????????????????????? ?????????????? ???? ?????????????????????????????????????? ???????????????? ?????? ???????????????? ?????????????????????????? ???????????? Omni-ITSN1 ?? Flag-SPRY2 ???? ???????????????????? ???????? ?????????????????? in vivo. ????????????????. ???????????????? ???????? ?????????????????????????? ?????????????????? ?????????????????????????? ?????????????????????? ?????????? ITSN1 ???? ???????????????????? ???????????? SPRY2 in vivo. ?????????????? ??????????: ?????????????????????? 1, ???????????????? ?????????????????????? ??????????????, SPRY2, ?????????? SH3.

???????????????? ?????????????????????? ?????????????? ???? RTK (?????????????????????? ?????????????????????? ??????????) ?????????? ?????????????? ?? ??????????????????????, ???????????????????????? ???? ????????????????. ?????????????????????? 1 (ITSN1) ??? ??????????????????????-???????????????????????????? ???????????????????? ??????????, ?????????????????????? ?? ?????????? ???????????? ???????????? ???????????????????????????????????????????? ????????????????????, ?? ?????????? ?? ?????????????????????????????? ?????????????????????????? ?? ???????????? ?????? ??????????????????????????????. ????????. ?????????? ????????????, ?????????????????? ???????????????????????? ?????????? ITSN1 ?? ?????????????????? ???????????????? ?????????????? ???? RTK. ????????????. ???????????????????????? ?????????????? ???????????????????????????? in silico, ???????????????????? ???????????? ?? ?????????????????????????? ?????????????? ?? ?? ???????????????? ???????????? ??????????????????????????, ????????????????????????????????????, ???????????????????????? ????????????, ???????????? ?? GST, ???????????????????????????????????????? ????????????. ????????????????????. ?? ?????????????????????? ?????????????? ??Scansite?? ?????????????????????? ???????????????????? ???????????? SH3A ITSN1 ?? SPRY2. ?????? ???????????????????????????????????? ?????????????????????????? ?????????? ???????????????????????????? GST-???????????? ???????????? ITSN1 ???????????????? ?? ?????????????? ???? ???????????? Escherichia coli. ?????????????????? ???????????????????????? ????????????, ???????????? ?? GST, ??????????????????????, ?????? ???????????? SH3A, N-SH3A (????????????-?????????????????????????? ??????????????), SH3C ?? SH3E ???????????????? ?????????????????????????????? SPRY2-Flag ???? ???????????? ????????????. ???????????? ?????????????????????????????????????????? ?????????????? ?? ???????????????????????????????????????? ?????????????????????????????? ?? ?????????????????? ?????????????????????????? ???????????? Omni-ITSN1 ?? Flag-SPRY2 ?? ???????????????????????? ?????? ?????????????????? in vivo. ????????????. ???????????????????? ???????????? ???????????????????????? ???????????????????? ?????????????????????????? ?????????????????????? ?????????? ITSN1 ?? ???????????????????? ???????????? SPRY2 in vivo. ???????????????? ??????????: ?????????????????????? 1, ???????????????? ?????????????????????? ??????????????, SPRY2, ?????????? SH3.

Related Organizations

National Academy of Sciences of Ukraine
Ukraine
Institute of Molecular Biology and Genetics
Ukraine

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