Additional file 1: Fig. S1. Chemokine receptor staining and corresponding negative controls. Representative images of A a negative control using only secondary antibody only and its corresponding B CCR5 staining is displayed. Furthermore, the C negative control for D CXCR5 and E CXCR6 staining is shown. Scale bars represent 50 µm. CCR C-C motif chemokine receptor, CXCR C-X-C motif chemokine receptor, DAPI 4',6-diamidino-2-phenylindole. Fig. S2. CXCL16 concentration in the serum comparing MP4-immunized mice with or without B cell aggregates. The significant increase in the CXCL16 concentration (pg/ml) in the serum of MP4-immunized mice without B cell aggregates compared to mice showing B cell aggregates (> 30 B cells) is displayed. Mean values ± SEM are shown. *p < 0.05, unpaired t-test, CXCL C-X-C motif chemokine ligand, SEM standard error of the mean. Table S1. Non-significant data of cytokines and chemokines in the CSF of different pathology groups. Table S2. Non-significant data of cytokines and chemokines in the CSF with reference to B cell aggregates. Table S3. Non-significant data of cytokines and chemokines in the serum of different pathology groups. Table S4. Non-significant data of cytokines and chemokines in the serum with reference to B cell aggregates.