Distribution of HLA-B27 and CYP2D6*4 mutations in the middle Black Sea area (Tokat) of Turkey
Copyright policy )Distribution of HLA-B27 and CYP2D6*4 mutations in the middle Black Sea area (Tokat) of Turkey
We analyzed distribution of HLA-B27 and CYP2D6*4 mutations in 249 patients from Tokat province in Turkey with symptoms of arthritis, sacroiliac, joint and back pain, using a LightCycler 480 II Real-Time PCR thermal cycler. The Genes-4U was applied for studying HLA-B27 mutation, and the Tib-Molbiol commercial kit was used to examine the CYP2D6*4 mutation. Among the 249 patients, 18.5% had the HLA-B27 mutation. The CYP2D6*4 mutation was found in 22.0% (six homozygotes). Ten patients had both mutations. These frequencies are similar to what has been reported from other populations.
- Gaziosmanpaşa University Turkey
HLA-B27, Turkey, Arthritis, Sacroiliac Joint, Real-Time Polymerase Chain Reaction, CYP2D6*4, Black Sea, Cytochrome P-450 CYP2D6, Back Pain, Mutation, Humans, HLA-B27 Antigen, Real-time PCR
HLA-B27, Turkey, Arthritis, Sacroiliac Joint, Real-Time Polymerase Chain Reaction, CYP2D6*4, Black Sea, Cytochrome P-450 CYP2D6, Back Pain, Mutation, Humans, HLA-B27 Antigen, Real-time PCR
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).4 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!