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Amyloidogenic peptide homologous to fragment 129–148 of human myocilin

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2013 English Publisher:Informa UK LimitedJournal:Prion, volume 7, pages 248-253 (issn: 1933-6896, eissn: 1933-690X,

Authors: N.A. Grudinina; Aram A. Shaldzhyan; A. K. Sirotkin; Dmitry V. Lebedev; Andrey V. Vasin; Michael M Shavlovsky; Alexander V. Slita; +1 Authors

doi: 10.4161/pri.24239

pmid: 23764838

pmc: PMC3783111

Amyloidogenic peptide homologous to fragment 129–148 of human myocilin

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Abstract

Myocilin is a protein with a molecular weight near 50 kDa. It is expressed in almost all organs and tissues. We showed that the peptide DQLETQTRELETAYSNLLRD corresponding to N-terminal Leucine zipper motif (LZM) of the protein is able to form amyloid-like fibrils. The possible role of this motif in myocilin aggregation is discussed.

Related Organizations

Ministry of Health
Russian Federation
Physical Sciences Division
Russian Federation
Kurchatov Institute
Russian Federation
Petersburg Nuclear Physics Institute
United States
Research Institute of Influenza
Russian Federation

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Keywords

Amyloid, Cytoskeletal Proteins, Leucine Zippers, Molecular Sequence Data, Humans, Amino Acid Sequence, Eye Proteins, Glycoproteins

20 Research products, page 1 of 2

Myocilin trabecular meshwork inducible glucocorticoid response isoform 5
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Mutant myocilin
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Myocilin
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Myocilin trabecular meshwork inducible glucocorticoid response isoform 1
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cDNA FLJ54185, highly similar to Myocilin
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Myocilin trabecular meshwork inducible glucocorticoid response isoform 3
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