Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae
Copyright policy )Plasma membrane proteins Slm1 and Slm2 mediate activation of the AGC kinase Ypk1 by TORC2 and sphingolipids in S. cerevisiae
The PH domain-containing proteins Slm1 and Slm2 were originally identified as substrates of the rapamycin-insensitive TOR complex 2 (TORC2) and as mediators of signaling by the lipid second messenger phosphatidyl-inositol-4,5-bisphosphate (PI4,5P2) in budding yeast S. cerevisiae. More recently, these proteins have been identified as critical effectors that facilitate phosphorylation and activation of the AGC kinases Ypk1 and Ypk2 by TORC2. Here, we review the molecular basis for this regulation as well as place it within the context of recent findings that have revealed Slm1/2 and TORC2-dependent phosphorylation of Ypk1 is coupled to the biosynthesis of complex sphingolipids and to their levels within the plasma membrane (PM) as well as other forms of PM stress. Together, these studies reveal the existence of an intricate homeostatic feedback mechanism, whereby the activity of these signaling components is linked to the biosynthesis of PM lipids according to cellular need.
- University of California, San Francisco United States
- University of Minnesota United States
- University of California, Davis United States
- University of California System United States
Feedback, Physiological, Extra Views, Sphingolipids, Saccharomyces cerevisiae Proteins, TOR Serine-Threonine Kinases, Cell Membrane, RNA-Binding Proteins, Mechanistic Target of Rapamycin Complex 2, Saccharomyces cerevisiae, Enzyme Activation, Cytoskeletal Proteins, Glycogen Synthase Kinase 3, Gene Expression Regulation, Fungal, Multiprotein Complexes, Humans, Phosphorylation, Carrier Proteins, Signal Transduction
Feedback, Physiological, Extra Views, Sphingolipids, Saccharomyces cerevisiae Proteins, TOR Serine-Threonine Kinases, Cell Membrane, RNA-Binding Proteins, Mechanistic Target of Rapamycin Complex 2, Saccharomyces cerevisiae, Enzyme Activation, Cytoskeletal Proteins, Glycogen Synthase Kinase 3, Gene Expression Regulation, Fungal, Multiprotein Complexes, Humans, Phosphorylation, Carrier Proteins, Signal Transduction
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