GATA-3 Regulates the Development and Function of Invariant NKT Cells
Copyright policy )GATA-3 Regulates the Development and Function of Invariant NKT Cells
Abstract Although invariant NKT (iNKT) cells participate in many aspects of immune responses, the molecular mechanisms regulating their development, maturation, and activation are still poorly understood. GATA-3 is a T cell-specific transcription factor that is also expressed in iNKT cells. The critical role of GATA-3 in conventional αβ T cells has been well documented, but whether GATA-3 also regulates the development and function of iNKT cells is unknown. In the present study, we report that deficiency of GATA-3 results in cell-intrinsic defects in the thymic development and peripheral maturation of murine iNKT cells. In addition, GATA-3 is also required for survival, activation, and effector functions of this unique population of T cells. Our data also reveal a previously unidentified peripheral maturation step that is GATA-3 dependent.
- University of Wisconsin System United States
- University of Wisconsin–Oshkosh United States
- Harvard University United States
- University of Wisconsin–Madison United States
- University of Birmingham United Kingdom
CD4-Positive T-Lymphocytes, Mice, Knockout, Cell Survival, Receptors, Antigen, T-Cell, Cell Differentiation, Galactosylceramides, GATA3 Transcription Factor, Thymus Gland, Lymphocyte Activation, Killer Cells, Natural, Mice, Inbred C57BL, Interferon-gamma, Mice, Th2 Cells, T-Lymphocyte Subsets, Injections, Intravenous, Animals, Cytokines, Spleen, Signal Transduction
CD4-Positive T-Lymphocytes, Mice, Knockout, Cell Survival, Receptors, Antigen, T-Cell, Cell Differentiation, Galactosylceramides, GATA3 Transcription Factor, Thymus Gland, Lymphocyte Activation, Killer Cells, Natural, Mice, Inbred C57BL, Interferon-gamma, Mice, Th2 Cells, T-Lymphocyte Subsets, Injections, Intravenous, Animals, Cytokines, Spleen, Signal Transduction
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