Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease
Copyright policy )Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease
Coronaviruses cause diseases in humans and livestock. The SARS-CoV-2 is infecting millions of human beings, with high morbidity and mortality worldwide. The main protease (Mpro) of coronavirus plays a pivotal role in viral replication and transcription, which, in theory, is an attractive drug target for antiviral drug development. It has been extensively discussed whether Xanthohumol is able to help COVID-19 patients. Here, we report that Xanthohumol, a small molecule in clinical trials from hops (Humulus lupulus), was a potent pan-inhibitor for various coronaviruses by targeting Mpro, for example, betacoronavirus SARS-CoV-2 (IC50 value of 1.53 μM), and alphacoronavirus PEDV (IC50 value of 7.51 μM). Xanthohumol inhibited Mpro activities in the enzymatical assays, while pretreatment with Xanthohumol restricted the SARS-CoV-2 and PEDV replication in Vero-E6 cells. Therefore, Xanthohumol is a potent pan-inhibitor of coronaviruses and an excellent lead compound for further drug development.
- Washington State University United States
- University of Mary United States
- FUDAN UNIVERSITY
- Fudan University
- Fudan University China (People's Republic of)
natural product, coronavirus, Virus Replication, Article, Catalytic Domain, Chlorocebus aethiops, Animals, Humans, Protease Inhibitors, Amino Acid Sequence, Vero Cells, Flavonoids, Biological Products, Propiophenones, Binding Sites, SARS-CoV-2, Xanthohumol, PEDV, 3C Viral Proteases, Alphacoronavirus, COVID-19, COVID-19 Drug Treatment, Coronavirus, Molecular Docking Simulation, Sequence Alignment
natural product, coronavirus, Virus Replication, Article, Catalytic Domain, Chlorocebus aethiops, Animals, Humans, Protease Inhibitors, Amino Acid Sequence, Vero Cells, Flavonoids, Biological Products, Propiophenones, Binding Sites, SARS-CoV-2, Xanthohumol, PEDV, 3C Viral Proteases, Alphacoronavirus, COVID-19, COVID-19 Drug Treatment, Coronavirus, Molecular Docking Simulation, Sequence Alignment
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