EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation
Copyright policy )EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation
Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1. We use the fact that specificity protein-1 (SP-1) is one of the crucial transcription factors of FBI-1, and that SP-1 can interact with the endothelial pas domain protein-1 (EPAS-1) for the induction of hypoxia related genes. The study showed that EPAS-1 plays an indispensible role in SP-1 transcription factor-mediated FBI-1 induction, and participated in tumor cell survival and proliferation. Thus, EPAS-1 could be a novel target for cancer therapeutics.
- Air Force Medical University China (People's Republic of)
Lung Neoplasms, Cell Survival, Sp1 Transcription Factor, Adenocarcinoma of Lung, Adenocarcinoma, Article, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, HEK293 Cells, factor binding IST-1; specificity protein-1; endothelial pas domain protein-1; transcription factor; tumorigenesis, Cell Line, Tumor, Basic Helix-Loop-Helix Transcription Factors, Humans, Cell Proliferation, Transcription Factors
Lung Neoplasms, Cell Survival, Sp1 Transcription Factor, Adenocarcinoma of Lung, Adenocarcinoma, Article, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, HEK293 Cells, factor binding IST-1; specificity protein-1; endothelial pas domain protein-1; transcription factor; tumorigenesis, Cell Line, Tumor, Basic Helix-Loop-Helix Transcription Factors, Humans, Cell Proliferation, Transcription Factors
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).9 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!